Evaluation of analgesic activity of methanolic extract of Trapa natans l.var. Bispinosa

Objective: The main objective of the present investigation is to evaluate the analgesic activity of methanolic extract of Trapa natans L.var. bispinosa Roxb. roots on mice.Materials & Methods: Analgesic activity of the methanolic extract of the T. bispinosa root at a dose of 200mg/kg & 400mg/kg was evaluated against the standard drug pentazocine at a dose of 30mg/kg. Adult Swiss albino mice of either sex of six numbers in each group was undertaken for study and evaluated by tail flick & tail immersion method.Results: The both doses of T. bispinosa roots methanolic extract was found to produce significant (p < 0.01) analgesic activity. In tail flick method, the extract at 200mg/kg showed significant activity (P<0.01) after 45 minutes but in tail immersion method, the extract showed significant activity at all tested dose levels after 30 minutes interval. The results showed significant analgesic activity against stimuli.Conclusion: The methanolic extract of Trapa natans L.var. bispinosa Roxb. roots have potential analgesic activity against stimuli in the tested animals. So, it can be recommened for further studies.