Salivary markers and periodontal symptoms in pancreatic cancer

Pancreatic cancer is one of the worst promising malignant neoplasms. Median survival rate in the group of patients is from two to six months. Early stage of the disease, which gives no symptoms or signs, already develops distant metastases. Thus, it is a molecular basis for functional and species variety of bacterial biofilm. It is necessary to come up with a simple, and reliable diagnostic tool in order to diagnose early stages of the neoplasm transformation. Four genes and one microbiologic marker were taken into account. Gene expression investigation (KRAS, ACRV1, DMX2, DPM1) and Streptococcus mitis titres are targets for diagnostic investigation and an attempt to explain pathomechanism of both diseases - pancreatic cancer and periodontitis on the molecular level. Furthermore, periodontal signs, visible on basic physical examination, might be oral manifestations of a systemic disease.