A Review of Biological potential of Pyrazinamide derivatives

Plan: A review on the importance of pyrazinamide derivatives for the treatment of tuberculosisPrologue: Tuberculosis is a chronic granulomatous disease and a major health problem in developing countries. Pyrazinamide (PZA) is an important front-line drug for the treatment of tuberculosis (TB). Pyrazinamide, along with isoniazid and rifampicin, forms the cornerstone of modern TB therapy. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target or to a change in titration of the drug. The problem of resistance demand to search and synthesize new classes of compounds effective against pathogenic microorganisms that have developed resistance to the drugs used in the current regimen.Outcome: In the present study, we have made an attempt to compile the reports on biological potential of pyrazinamide and its derivatives. The pyrazinamide derivatives possess unexplored potential that can be utilized for the development of new chemical entities (NCEs) to treat the mycobacterial infections.