Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives

Plan: Anti-inflammatory evaluation of acid hydrazide derivatives.Prologue: Hydrazide derivatives of organic compounds forms a significant group of derivatives which exhibit an array of biological activities like anti-inflammatory, antibacterial, antifungal, anti-neoplastic, antiviral etc. In view of above facts, we hereby reported the anti-inflammatory evaluation of selected most active eight antimicrobial acid (nicotinic acid, naphthalene-1-acetic acid and 2-naphthoxy acetic acid) hydrazide derivatives.Methodology: The anti-inflammatory activity of reported hydrazide derivatives determined by carrageenan induced paw oedema method and diclofenac sodium as standard drug.Outcome: Anti-inflammatory activity showed that nicotinic acid hydrazide derivatives with NO2 substituents at ortho and meta position were the most active ones among the selected hydrazide derivatives, having 35.73% and 37.29%; 25.12% and 34.17% inhibition, at two different doses 20 mg/kg and 50 mg/kg b.w., respectively.