Anti diabetic activity of Dolichos lablab (seeds) in Streptozotocin- Nicotinamide induced diabetic rats

Plan: The present study was designedto investigate the antidiabetic activity of methanolic extract of Dolichoslablab seeds.Preface: Intraditional medicine plants are generally used for treatment of various acuteand chronic disease and abnormalities in the body. Due to the present fast lifeof the human a drastic increase in chronic disease conditions mainly diabeteshas been determined. The present study therefore justifies its use in the folkloreremedies as an antidiabetic drug of natural origin.Methodology: Antidiabeticactivity was evaluated by Streptozocin-Nicotinamide induced diabetic model. Themethanolic extract of the seeds of Dolichos lablab was given by Oral route atdoses of 200mg/kg and 400mg/kg b.wt.Outcome: Treated diabeticrats with MEDL dose dependely(P<0.001) reduced blood glucose levels, totalcholesterol, triglycerides, SGPT, SGOT levels compared to untreated diabeticrats in STZ induced diabetic model. MEDL 400mg/kg b.wt was found to possessmore promising antidiabetic activity compared to 200mg/kg b.wt