Evaluation of the Antibacterial Potential of various solvent extracts of Acacia nilotica linn. Leaves

Plan: Bioactive compounds of leaves of Acacia nilotica Linn. (Malvaceae) have been studied for their antimicrobial activities using disc diffusion assay.Methodology: Four Gram negative bacteria (Escherichia coli MTCC 2961, Pseudomonas aeruginosa MTCC 4676, Klebsiella pneumoniae MTCC 432 and Salmonella typhi MTCC 733), two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) were selected for the study. Minimum inhibitory concentration (MIC) of the active compounds was evaluated by micro broth dilution method.Outcome: All the active compounds exhibited broad spectrum antimicrobial activity. Alkaloids and Flavonoides were found to be more potent. S. aureus was found to be most susceptible organism followed by E. coli and S.typhi. Our findings confirm that the traditional therapeutic claims for this plant, in near future surely be able to replace the conventional antimicrobial agents to which there is increased incidence of drug interactions and the study suggests that this plant is promising for development of phytomedicines with antibacterial properties.