Drug Delivery using genetically modified Mesenchymal Stem Cells: A promising targeted-delivery method

Plan: The review covers the uniquerole of Mesenchymal stem cells to improve, the poor solubility, prematuremetabolic inactivation, excretion and bioavailability of different classes ofdrugs which are insoluble or sparingly soluble in water.Preface: Mesenchymal stem cells (MSCs)exhibit unique characteristics including their ability to differentiate andmigrate to sites of tissue injury/inflammation, genetic modifiability, andexpression of protein. Many of the most promising drug targets areintracellular and can only be accessed by drugs capable of traversing the cellmembrane. Gene and drug delivery using genetically modified cells offersseveral unique advantages including ease of modifying, inducible or continuousdrug production inside the body, more control on drug target and safety.Outcome: In this review article, weexamine the promising of using MSCs as a drug delivery vehicle for genetherapy, and summarize various challenges and concerns regarding thesetherapies.Key words: Mesenchymal stem cell, Drugdelivery, Gene delivery