Proton pump - key cell element in acid related digestive disorders

Proton pump is the final step in gastric acid secretion, its physiopathological and pharmacological importance being undeniable in acid related digestive disorders. The knowledge of the intimate mechanisms of gastric secretion and the interaction of ATP-ase (adenosine triphosphatase) with various cell proteins is essential in finding efficient and specific inhibitors in order to cure these diseases. The article proposes a synthesis of the most recent acquisitions in decoding gastric secretion mechanism, interaction between proton pump inhibitors (PPI) and the K/HATP-ase and in the main directions of studying the ATP-ase.