IMPORTANCE OF THE GLYCOREGULATION IN THE CORONARY HEART DISEASE PATHOGENESIS IN DIABETES MELITUS

Despite some research studies pointing to the importance of poorglycoregulation and the emergence of the coronary heart disease (CHD) in thepatients suffering from diabetes, the strength of relation between these twophenomena is still not clear enough.The aim of the paper is to examine the importance of the glycoregulationdisturbance fot the emergence of a coronary heart disease in insulin-independentpatients. The methods for estimating glycoregulation comprised: the determinationof a morning glycemia on an empty stomach, the determination of a daily glycemiaprofile by taking 5 capillary blood samples in a day and determining the mediumvalue of the daily profile.By comparing the glycemia profiles in the examined patients a statisticallyimportant difference among the medium glycemia values was found in each of theexamined groups. In the dyslipodemic patients with a CHD the glycemia values were considerably larger in ali the daily measurements and the medium daily profile ofglycemia (MBG) amounted to 9.77+2.47 mmol/1, while in the patients without anycoronary disease they amounted to 7.8+1.74 mmoI/L An important correlation wasfound between the triglyceride values and the morning glycemia (C=0.48) in thediabetes patients with the CHD, while in the diabetes patients without any CHD apositive correlation of the MBG values with cholesterol (C=0.54) and triglycerides(C=0.48) was found. A strong negative correlation in this group was shown for theHDL cholesterol (C=0.7). Ali this reveals a joint relation between hyperglycemia andlipid disturbances with a cumulative effect upon the emergence of the CHD in theNIDDM patients.