THE EFFECTS OF ENALAPRIL ON UREA AND CREATININE SERUM CONCENTRATION AND PAS COLORING MORPHOLOGICAL CHANGES IN EXPERIMENTAL GENTAMICIN NEPHROTOXICITY

The effects of Enalapril on glomerular changes and desquamation of tubular epithel in rats were analyzed in Gentamicin nephrotoxicity. It was detected necrosis and epithel desquamation of proximal tubules and degenerative changes in glomerular at animals treated by Gentamicin (100 mg/kg body mass/24 h). Nephron morphological changes were more intensive and extensive by simultaneous treatment of Gentamicin and Enalapril. In animals, treated by Gentamicin it appeared the increasing of urea (p<0,001) and creatinine (p<0,001) comparing to the control group. The combination of Enalapril and Gentamicin resulted bigger kidney damage then Gentamicin itself, so the level of urea concentration in serum (p<0,001) and creatinine concentration (p<0,05) was higher in the third experimental group. Our biochemical results are according to the PAS coloring morphological changes found in kidney. Consequently, our findings support hypothesis that Enalapril causes exacerbating of Gentamicin nephrotoxicity.