CHANGE OF THE ENZYME SDH ACTIVITY IN THE LIVER AND OF THE BIOCHEMICAL PARAMETERS IN THE BLOOD OF THE RATS TREATED WITH GENTAMICIN

The change of the enzyme SDH activity in the liver as well as the change of the biochemical parameters (sGOT, sGPT and bilirubins) in the blood of the rats treated with gentamicin. In the experimental group of animals treated with gentamicin (100 mg/kg TT/24 h) for eight days it was found that the highest SDH activity was in the peri venular zone of the acinus (+++), that the enzyme's reduced activity was in the intermediary zone (+) and that the SDH activity in the per portal zone of the acinus was just in traces (+). In the control group of animals treated with the physiological solution (1 ml/kg TT/24 h), the enzyme SDH activity was the most prominent in the perivenular zone of the acinus (+++), while in the intermediary and the periportal zone the enzyme's activity was preserved but somewhat weaker (++). The results of the comparative study of enzymohistochemical and biochemical changes confirm the existence of an important correlation between the gentamicin application and the observed changes.