INFLUENCE OF HIGH CORTISOL DOSES UPON THE SERUM IMMUNOGLOBULIN LEVEL

The effects of Cortisol upon the serum immunoglobulin concentration areexamined. The experiment involved male guinea pigs of the body weight from 300 to400 g that were nonnally fed and lived under the common laboratory conditions. Theguinea pigs were divided into an experimental and a control group. The experimentalgroup's guinea pigs were given every day (in a 6 days' period) a subcutaneous dose of80 g of corti sol/kg/per day, while the control group ones were given only one ml ofthe physiological solution. Two weeks after the last received dose of Cortisol orphysiological solution the cordial puncture was applied to take a blood sample inwhich the level of the serum IgA, IgG and IgM was determined. In the experimentalgroup animals the serum IgG value was 11,2 mg/ml at the beginning and 8,7 mg/ml at the end of the experiment (reduction for 22,1%), while the TgA concentration at theend of the experiment was reduced for 5,8%, while the IgM concentration for 12,9%.The serum immunoglobulin concentration in the control group guinea pigs does notreveal any significant differences at the beginning and the end of the experiment.