DIABETIC DYSLIPIDEMIA AND OXIDATIVE STRESS – THEIR CUMULATIVE EFFECTS ON DEVELOPMENT OF CORONARY HEART DISEASE

Lipid disorders are most common findings in diabetes mellitus type 2 with significant role in etiopathogenesis of coronary heart disease (CHD). The main role in this process belongs to the oxidatively modified LDL particle. The aim of the work was to determine characteristic lipid profile and intensity of oxidative stress as well as their cumulative effect in pathogenesis of CHD. We examined 60 type 2 diabetics divided into two groups: with CHD and without CHD. Besides taking the anamnesis and performing the physical examination, we determined parameters of oxidative stress in blood. We found higher degree of obesity in group with CHD 29.67±3.31 vs. 27.87±3.17 kg/ m2 (p<0.05). Lipid parameters and lipid risk levels did not vary statistically between these two groups. Atherogenic index LDL-C/HDL-C is higher in patients with CHD 4.47±1.62 vs. 3.85±1.39. There is a marked prevalence of hypercholesterolemic patients (58%,), while combined dyslipidemia (34% )and hypertriglyceridemia (8%) of diabetics was present to a lesser degree. In the serum of diabetics without CHD, protective activity of catalase is significantly higher 11.07±2.11 vs. 9.563±2.291, while lipid peroxydation degree is significantly lower 3.41±2.16 vs. 5.19±3.44 compared to patients with CHD (p < 0.05). Moreover, in the group with CHD there is a significant negative correlation between catalase activity and level of LDL-cholesterol (-0.86, p < 0.05). The obtained results confirm this cumulative effect of lipid disturbances and oxidative stress in pathogenesis of CHD, as well as importance of antilipemic therapy.