Research:LIV.52 IN ALCOHOLIC HEPATITIS

Alcoholic Hepatitis is a leading cause of morbidity and mortality in India.There is no specific treatment for alcoholic hepatitis. Liv.52 has been reported to many workers to be effective in the treatment of infectious hepatitis. The study focuces on the effect of the Liv.52 therapy in alcoholic hepatitis for protection of liver with the help of investigating liver marker enzymes, antioxidant enzymes, lipid peroxidation and antioxidant vitamins. Present study includes well diagnosed 50 alcoholic hepatitis patients in between 33 to 55 years. The laboratory is equipped with semiautoanalyzer hence all investigations were carried out on semiautoanalyzer. Data were statisticaly analyzed by using the stastical pakage for social sciences (SPSS) version 10.0. Oxidative stress was assessed by estimating lipid peroxidation [LPO]. Activity of enzymatic antioxidants (superoxide dismutase [SOD], glutathione peroxidase [GPx], catalase) and heart profile enzymes, creatine kinase [CK-MB], lactate dehydrogenase [LDH], aspartate aminotransferase [AST] were measured.The activity of enzymatic antioxidants were reduced in hepatitis and this decreased activity significantly raised and comes near the normal range after 8 weeks therapy. The activity of liver profile enzymes has been comes to the normal range after the 8 weeks interval therapy of Liv.52. This study strongly suggests that the therapy with Liv.52 increases antioxidants and reduces lipid peroxidation of hepatic cellular and intracellular membranes and protects liver damage due to free radicals in alcoholic hepatitis.