Research: A STUDY OF LDH ISOENZYME SUBUNIT IN THE DIFFERENTIAL DIAGNOSIS OF CEREBROVASCULAR DISEASE & BRAIN TUMOR

Lactate dehdrogenase (LDH) is a zinc containing enzyme which is present in abundance in brain.This study evaluated the concentration of LDH as well as its isoenzyme subunit ratio (H: M) in the cerebrospinal fluid (CSF) among patients with various neurological and Non neurological cases. Total LDH activity was significantly increased in all the study groups (cerebrovascular accident group, Neurological cases group and brain tumor cases) as compared to Control group (non-neurological cases). Moreover the current study also suggest that the isoenzyme subunit ratio H/M was significantly decreased (p<0.001) in all the study groups as compared to non-neurological Control group. Therefore finding the LDH along with its subunit ratio may be helpful to know the disease progression better and may help in efficient treatment and assessment of neurological disease status.