Research: SPECTROPHOTOMETRIC SIMULTANEOUS DETERMINATION OF HYDROCHLOROTHIAZIDE AND TELMISARTAN IN COMBINED DOSAGE FORM BY DUAL WAVELENGTH METHOD

Simple, sensitive, specific and economic spectrophotometric method was developed and validated for simultaneous estimation of Hydrochlorothiazide and Telmisartan in tablet dosage form. New method based on the simultaneous estimation of drugs in a binary mixture without previous separation was developed. In dual wavelength method, Hydrochlorothiazide and Telmisartan were quantified using principle that absorbance difference between two points on mixture spectra is directly proportional to concentration of component of interest and independent of interfering component. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The method permits simple, rapid and direct determination of Hydrochlorothiazide and Telmisartan in commercially available tablet dosage form without previous separations and can therefore be used for routine analysis of both drugs in quality control laboratories.