Review: BUOYANT SUSTAINED RELEASE DRUG DELIVERY SYSTEMS CURRENT POTENTIALS ADVANCEMENTS AND ROLE OF POLYMERS: A REVIEW

Controlled and sustained released formulations are widely used in modern era for the delivery of variousingredients. Drugs with narrow absorption window in the gastrointestinal tract have poor absorption thereforegastroretentive drug delivery systems (GRDDs) have been developed which prolong the gastric emptying time. Ofthis many techniques like floating, high density mucoadhesive microspheres in situ gelling systems etc, are utilizedto deliver the drug to the better site where it is absorbed. All pharmaceutical dosage forms contain many additivesbesides the active ingredients to assist manufacturing and to obtain the desired effect polymers have beensuccessfully employed in the formulations to sustain the release of drug. Both the natural and synthetic polymersare employed in this process. This review discuss about the basic physiology of GIT, techniques polymers (naturaland synthetic) and recent advancements in GRDDs.