Biological Screening Procedures For Anti-Diabetic Drugs

Diabetes is a complex and heterogeneous disorder presently affecting more than 100 million people worldwide and causing serious socio-economic problems. Appropriate experimental models are essential tools for understanding the pathogenesis, complications, and genetic or environmental influences that increase the risks of type 2 diabetes and testing of various therapeutic agents. The animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations and/or by combination thereof. This review gives an overview on the animal models of type 2 diabetes with reference to their source, characteristic features, underlying principal and procedure to the investigators in diabetes research 1,2. Diabetes can be divided into two groups based on their requirements for insulin: - ·Type 1 : Insulin- dependent diabetes mellitus [IDDM] ·Type 2 : Non- insulin dependent diabetes [NIDDM]