Antithrombotic therapy: current status and future developments

Thrombosis is one of the major causes of death worldwide and is a socioeconomic burden to the society. Continuous increase in the knowledge about the (patho)-physiological changes associated with thrombosis led to the development of effective therapies (antiplatelet, anticoagulant and thrombolytic therapy) for the prevention and the treatment of the disease. However, better understanding of the underlying processes is still crucial for the development of more effective and safer antithrombotic drugs. The aim of the current review is to provide an updated overview of the causes and classes of thrombosis, to summarize currently available treatment and problems associated with it; and to highlight new antithrombotic agents in the developmental stages with future prospective.