Colon Targeted Pulsatile Drug Delivery : A Review

Over the past two decades the major challenge for scientist is to target the drugs specifically to the colonic region of g.i.t. Previously colon was considered as a innocuous organ solely responsible for absorption of water, electrolytes & temporary storage of stools. But now it is accepted as important site for drug delivery. colon is used to treat – Seriousness from constipation & diarrhoea to the debilitating inflammatory bowl diseases (ulcerative colitis & Crohn’s disease) through to colon carcinoma which is two third cause of cancer in both man & women. Colon can be utilized as portal for the entry of drugs into the blood stream for the systemic therapy. Colon having the lower level of luminal & mucosal digestive enzymes as compared with the small intestine reduces the chances of drug degradation. Colon delivery also a mean of achieving chronotherapy of disease that are sensitive to circadian rhythm such as asthma & arthritis. Targeted delivery ensures the direct treatment at the disease site, lower dosing, & reduction in side effects. 1, 2