Computer Assisted Drug Design (HIV-1 NNRTIs)

Acquired Immuno Deficiency Syndrome (AIDS) is a systemic and fatal disorder produced by Human Immuno deficiency Virus (HIV), which is retrovirus of the lentivirus family originally reffered to HILV-III or Lav. By leading to the destuction &/or functional impairement of cells of immune system, notably CD4+ T cells.HIV progressively destroys the body’s ability to fight infection leads to severe depletion of CD4+ T-lymphcytes resulting in opportunistic infection,neurologic and neoplastic disease and ultimately death. Identification of molecular events critical to virus replication has enabled the solution of several strategies for potential chemotherapeutic intervention.