Specialized chronotherapeutic drug delivery systems

In the field of modified release, matching of drug release to the body’scircadian rhythms have been fundamental strategies involves for selecting a newdrug delivery system which increase the efficacy and safety of drugs byproportioning their peak plasma concentrations during the 24 hours in synchronywith biological rhythm. Inparticular, the recent literature reports on a variety of chronotherapeuticdrug delivery systems, which have been recognized as potentially beneficial tothe chronotherapy of widespread chronic diseases that display time-dependentsymptoms such as ulcers, asthma and cardiovascular disease. Such chronotherapeutic drug delivery systemcontrols drug release according to circadian rhythms and the timing ofsymptoms. The aim of this review is to outline the differentmethodologies used to develop chronotherapeutic drug delivery systems.