Reacciones adversas e interacciones medicamentosas en pacientes con edema cerebral

Se realizó un estudio en la Unidad de Cuidados Intensivos e Intermedios del Hospital Clinicoquirúrgico Docente "Saturnino Lora" de Santiago de Cuba, con el objetivo de evaluar reacciones adversas e interacciones medicamentosas detectadas en el tratamiento del edema cerebral. Se aplicó el método de vigilancia intensiva del paciente hospitalizado, adaptado a las condiciones experimentales en una muestra de 65 pacientes. Los datos obtenidos se evaluaron por medio de los algoritmos de Naranjo y de Karch-Lasagna, así como la relación beneficio-riesgo de cada tratamiento y el procesamiento estadístico apropiado. Se detectaron 114 reacciones adversas y 40 interacciones medicamentosas; eventos que luego de relacionarlos con aspectos clínicos y demográficos, se analizaron farmacológicamente. Se proponen medidas terapéuticas al personal del servicio y recomendaciones al paciente, para atenuar los riesgos que pueden ocasionarle los tratamientos aplicados. A study was carried out in the Intensive and Intermediate Care Units of "Saturnino Lora" Teaching Clinicosurgical Hospital with the purporse of assessing adverse drug reactions and drug interactions detected in treating brain edema. The method of intensive surveillance of the hospitalized patients was used in a sample of 65 cases accoirding to set experimental conditions. Date obtained was evaluated by Narnajo’s and Karch-Lasagna’s algoritthms and also, benefit-risk of each treatment and adequate statistical processing were also analysed. 114 adverse drug reactions and 40 drug interactions were detected, wihch were first related to clinical and demographic aspects and then pharmacologically analyzed. Therapeutic measures for the staff were proposed as well as recommendations for patients were made so as to reduce the risks that treatments may cause.