A FACILE ONE-POT SYNTHESIS OF NOVEL 1,1′-(ALKANEDIYL)BIS(5-OXO-3- ALKYL/ARALKYL/ARYL-1,2,3,4,5,6,7,8-OCTAHYDROQUINAZOLINES and THEIR ANTI-BACTERIAL ACTIVITIES A FACILE ONE-POT Synthese von neuartigen 1,1 '- (Alkandiyl) BIS (5-oxo-3- ALKYL/ARALKYL/ARYL-1,2,3,4,5,6,7,8-OCTAHYDROQUINAZOLINES and their Anti-bakterielle AKTIVIT TEN

A facile one-pot synthesis of novel 1,1′-(alkanediyl)bis(5-oxo-3-alkyl/aralkyl/aryl- 1,2,3,4,5,6,7,8-octahydroquinazolines) 3a-r has been devised by the cyclocondensation of bisenaminones 2a-f with primary amine and formaldehyde. The structures of the products have been established by spectral and analytical data as 1, 1′-(alkanediyl)bis(5-oxo-3-alkyl/ aralkyl/aryl-1,2,3,4,5,6,7,8-octahydroquinazolines). Some of the compounds have been found to possess promising anti-bacterial properties.