SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 3-{6-[3-(SUBSTITUTED PHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]-2-THIOXO-1,2,5,6-TETRAHYDROPYRIMIDIN-4-YL}-2H-CHROMEN-2-ONES Synthese und biologische AKTIVIT TEN VON 3 - {6 - [3 - (substituiertes Phenyl) -1-PHENYL-1H-PYRAZOL-4-YL]-2-thioxo-1 ,2,5,6-tetrahydropyrimidin-4-YL}-2H-chromen-2-onen

Reaction of synthon 3-acetyl-2H-chromen-2-one (1) with 3-substituted aryl-1-phenylpyrazol carboxaldehyde (2a-d) gave intermediate compounds 3-[3-(3-substituted aryl-1-phenylpyrazol-4- yl)acryloyl]-2H-chromen-2-ones (3a-d). These chalcones upon cyclization with thiourea yielded desired target compounds (4a-d) in 46-62% yield. All the synthesized compounds were characterized by spectral data such as IR, 1H NMR and mass spectra. These compounds were also screened for their antimicrobial and antioxidant activities.