SYNTHESIS AND ANTIMICROBIAL SCREENING OF NOVEL ISOXAZOLYL THIAZOLO[5,4-d] PYRIMIDINE-2,5-(1H,4H)-DITHIONES SYNTHESIS und antimikrobielle Screening nach neuen Isoxazolyl Thiazolo [5,4-d] PYRIMIDIN-2, 5 - (1H, 4H)-Dithione

The synthesis of novel isoxazolyl thiazolo[5,4-d]pyrimidine-2,5-(1H,4H)-dithiones (7a-h) were achieved by the cyclocondensation of isoxazole amine (1) with chloro acetic acid (2) and carbon disulfide (3) in presence of piperidine followed by cyclization with aromatic aldehyde (5) and thiourea (6). All the compounds synthesized 4a-h and 7a-h were characterized on the basis of their IR, 1H NMR,13C NMR and mass spectral data and screened for their antimicrobial activity.