RECENT DEVELOPMENTS IN FLUORINATION CHEMISTRY OF DAST WITH SPECIAL REFERENCE TO ALCOHOLS AKTUELLE ENTWICKLUNGEN IN DER CHEMIE FLUORIERUNG DAST MIT SPECIAL VERWEIS AUF ALCOHOLS

Fluorine containing organic compounds have influenced both medicinal and agrochemical fields.The presence of fluorine or a fluorine containing group causes notable changes in the physical and chemical properties of ordinary organic compounds.The most significant method to introduce fluorine into organic compounds is the nucleophilic replacement of oxygen with fluorine. Diethylaminosulfur trifluoride (DAST), Bis(2-methoxyethyl)aminosulfur trifluoride (BAST) or deoxofluor are the popular fluorinating reagents. By the use of these reagents, organic compounds that contain oxygen in hydroxyl and carbonyl groups are readily converted into their corresponding fluorinated analogues by the introduction of one or two fluorine atoms respectively. Our interest in applying various synthetic methods to incorporate fluorine or a fluorinated group into a large variety of organic compounds encouraged us to summarize the recent chemistry of DAST