GLYCOLIC ACID AS A NOVEL AND GREEN SOLVENT FOR THE PREPARATION OF 3, 4-DIHYDROPYRIMIDIN-2(1H)-ONES Glykols ure als eine neuartige und GREEN L sungsmittel für die Herstellung Von 3, 4-dihydropyrimidin-2 (1H)-one.

Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H)-one derivatives. This synthesis was performed using glycolic acid as a green acidic solvent. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields and simple procedure.