A NEW PATHWAY FOR THE PREPARATION OF 3-SUBSTITUTED 1,2,4- OXADIAZEPINES BY INTRAMOLECULAR PALLADIUM CATALYZED CYCLIZATION OF (E)-O-(2-IODOPHENYLMETHYL) AMIDOXIMES Ein neuer Weg FüR DIE VORBEREITUNG von 3-substituierten 1,2,4 - OXADIAZEPINES durch intramolekulare Palladium-katalysierten Cyclisierung der (E)-O-(2-IODOPHENYLMETHYL) Amidoxime

DOI: october 27, 2011.

Keywords: Palladium catalyst, coupling, amidoximes, o-iodobenzyl bromid, phase transfer catalysis, 3-substituted 1 , 2 , 4-oxadiazepines.

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Abstract:

A simple synthesis of novel class of heterocyclic compounds - 3-substituted 1,2,4-oxadiazepines from corresponding (E)-O-(2-iodophenylmethyl)amidoximes in the system Pd2(dba)3/ Xantphos / solid Cs2CO3 / dioxane has been developed.

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