SYNTHESIS, DOCKING AND BIOLOGICAL EVALUATION OF 1,4–DIHYDROPYRIDINE DERIVATIVES SYNTHESIS, DOCKING und biologische Evaluierung von 1,4 -Dihydropyridinderivaten

In the present study, a novel series of 1,4-dihydropyridine derivatives were synthesized and docking study was performed to rationalize the possible interactions between the synthesized compounds and active site.1,4-dihydropyridine derivatives were designed as Enoyl-acyl carrier protein reductase inhibitors. All compounds were screened for antimycobacterial activity against M.tuberculosis H37Rv using Microplate Alamar Blue Assay. Pyrazinamide (PZA) and Streptomycin were employed as the reference antimycobacterial agents. Among the series S1 found to be most potent while S2, S3, S4, S5, S6 were found to be less potent than S1. Keywords: Antimycobacterial; Docking, MABA, Enoyl-acyl carrier protein reductase