SOLVENT-FREE SPLENDID ONE POT SYNTHESIS OF 2-AMINO-6-(SUBSTITUTEDPHENYL)-5-METHYLPYRIMIDIN-4-OL USING PEG-400 L SEMITTELFREIE SPLENDID Eintopfsynthese von 2-Amino-6-(SUBSTITUTEDPHENYL)-5-methylpyrimidin-4-ol mit PEG-400

The simple and efficient approach towards one step synthesis of 2-amino-6-(substitutedphenyl)- 5-methylpyrimidin-4-ol derivatives has been developed by three component condensation of aromatic aldehydes, ethyl propionate and guanidine hydrochloride using PEG as reaction medium.