SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME THIAZOLIDINONE DERIVATIVES INCORPORATING WITH PHENOTHIAZINE MOIETY SYNTHESE UND antituberkul se Aktivit t einiger Thiazolidinon Derivate, die mit Phenothiazin-Einheit

A novel series of 4-thiazolidinone derivatives (5a-g) incorporating with Phenothiazine moiety via mannich reaction were synthesized by the reaction of 4-[Phenothiazin- 10-ylmethyl)-amino]-benzoic acid benzylidene hydrazide (4a-g) with mercapto acetic acid in the presence of anhy., ZnCl2. The chemical structures of newly synthesized compounds were elucidated by IR, H NMR, 13 C NMR, Mass spectral data. The compounds (5a-g) were evaluated for their anti tubercular activity against M. Tuberculosis H37Rv. Some of the compounds were showed appreciable anti-tubercular activity comparing with standard drug. Furthermore the compounds (5a-g) were screened for their antimicrobial activity against various bacterial and fungal strains.