Usefulness of Serum Prolactin in Differentiating Epileptic and Pseudoseizures in

Transient hyperprolectinemia has been reported to follow unprovoked seizures. This study was conducted in 90children aged 1-18 years of age. The study comprised of four groups: Group-1 consisted of children with epilepsy whichwas further subdivided into GTCS, CPS and SPS. Group-2 comprised of children having febrile convulsions. Group-3comprised of children suffering from non-epileptic paroxysmal events like breath holding spell, syncope and pseudoseizuresor conversion reaction. Group-4 consisted of children who served as controls. Blood sample was collected within twohours of the event in all the groups. The exact interval between the event and the collection of blood sample was noted.Serum prolactin level was estimated by ELISA technique. In the present study, significant elevation of serum prolactinlevel was observed only in the Group-1 (28.77+15.49ng/ml) as compared to controls (9.53+2.45ng/ml) and the highestlevels were observed in children with GTCS. Maximum elevation of prolactin was seen within 15 to 30 minutes post ictally.As the prolactin levels become normal after two hours of post ictal period, the test looses its significance.