The prognostic value of different glucose abnormalities in patients with acute myocardial infarction treated invasively

To assess the incidence and impact of GA on clinical outcomes in AMI patients treated with percutaneous coronary intervention (PCI).A single-center, prospective registry encompassed 2733 consecutive AMI subjects treated with PCI. In all in-hospital survivors (n？=？2527, 92.5%) without the history of DM diagnosed before or during index hospitalization standard oral glucose tolerance test (OGTT) was performed during stable condition before hospital discharge and interpreted according to WHO criteria. The mean follow-up period was 37.5？months.The incidence of GA was as follows: impaired fasting glycaemia - IFG (n？=？376, 15%); impaired glucose tolerance - IGT (n = 560, 22%); DM (n？=？425, 17%); new onset DM (n？=？384, 15%); and normal glucose tolerance – NGT (n？=？782, 31%). During the long-term follow-up, death rate events for previously known DM, new onset DM and IGT were significantly more frequent than those for IFG and NGT (12.3; 9.6 and 9.4 vs. 5.6 and 6.4%, respectively, P？<？0.05). The strongest and common independent predictors of death in GA patients were glomerular filtration rate？<？60？ml/min/1,73？m^2 (HR 2.0 and 2.8) and left ventricle ejection fraction？<？35% (HR 2.5 and 1.8, all P？<？0.05) respectively.Glucose abnormalities are very common in AMI patients. DM, new onset DM and IGT increase remote mortality. Impaired glucose tolerance bears similar long-term prognosis as diabetes.The prevalence of type 2 diabetes mellitus (DM) has rapidly increased worldwide over the last decades and DM is increasingly perceived as an ongoing epidemic. There is a conclusive evidence implicating DM in complications of coronary heart disease (CHD) [1], [2], [3] and [4]. The risk of acute myocardial infarction (AMI) and death in diabetic subjects without CHD is similar to the risk of non-diabetic pts with previous AMI. Therefore, DM has gained the status of CHD risk equivalent [5]. Despite recent treatment improvements of AMI, patients with DM have worse prognosis after myocardial in