Study of effects of aluminium chloride on histological structure of liver and spleen in pregnant rats and their offspring

Histological study of organs reflects the General State of animals, including, if they are subject to treatment. The purpose of our study is to elucidate the effect of the administration of different doses (50, 100 and 200 mg/Kg/day) of aluminum chloride during the days 9-13 of gestation on the histological structure of the liver and the spleen of pregnant rats and their offspring. In pregnant rats, AlCl3 leads, at the level of the liver, to a very important development of the connective tissue of the centrilobular vein, with inflammatory foci and hepatocyte injury. While at the level of the spleen, there is a development of the white pulp against the red pulp with an abundance of conjunctive fibres and dilation of the lining of arterioles, which reflects a failure of the circulatory system. The fetuses of rats treated by AlCl3, show no change in the histological structure of the spleen. The AlCl3 action is more marked than mothers in their fetuses. This certifies that the placenta forms a more or less selective barrier to some constituents, and that spleen in fetuses temporarily offset the effects of AlCl3