ECO FRIENDLY ROUTE OF DEHYDROGENATION OF 2,3-DIHYDRO-2-PHENYL-4-QUINOLONE TO 2-PHENYL-4-QUINOLONE USING DIACETOXY IODO BENZENE

As an alternative reagent to various traditional dehydrogenating reagentsDiacetoxy iodo benzene is stable, non-hazardous, acidic and has been successfully usedfor dehydrogenation reactions1.Herein we report a new and ecofriendly route for dehydrogenation of 2,3-dihydro-2-phenyl-4-quinolone to 2-phenyl-4-quinolone using diacetoxy iodo benzene andpotassium hydroxide2.A series of 2,3-dihydro-2-phenyl-4-quinolones3 has been synthesized usingacid-catalyzed one-pot reaction quinolones were prepared through cyclization of thecondensation product that were formed by heating of arylamines and ethylbenzoylacetate in toluene. Similarly, the 6 (7 or 8)-substituted 2,3-dihydro-2-phenylquinolones were prepared from the para (ortho or meta)-substituted aniline.