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BMC Cancer  2011 

Prognostic significance of CD44s expression in resected non-small cell lung cancer

DOI: 10.1186/1471-2407-11-340

Keywords: non-small cell lung cancer, CD44s, immunohistochemistry, prognosis

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Abstract:

Using immunohistochemical staining, we investigated CD44s protein expression using tissue array specimens from 159 patients with resected NSCLC (adenocarcinoma (AC; n = 82) and squamous cell carcinoma (SCC; n = 77). Additionally, the immunoreactivity of cyclooxygenase (COX)-2 was also studied. The clinicopathological implications of these molecules were analyzed statistically.High CD44s expression was detected more frequently in NSCLC patients with SCC (66/72; 91.7%) than in those with AC histology (P < 0.001). Additionally, high CD44s expression was significant correlated with more advanced regional lymph node metastasis (P = 0.021). In multivariate analysis of survival in NSCLC patients with AC histology, significant predictors were lymph node metastasis status (P < 0.001), high-grade tumor differentiation (P = 0.046), and high CD44s expression (P = 0.014). For NSCLC patients with SCC histology, the significant predictor was a more advanced tumor stage (P = 0.015). No significant association was found between CD44s and clinical outcome (P = 0.311).High CD44s expression was a negative prognostic marker with significance in patients with resected NSCLC, particularly those with AC histology, and was independent of tumor stage.Cell adhesion molecules control cell behavior through interactions with each other and with their microenvironment by exchanging information through cell-cell and cell-extracellular matrix (ECM) interactions [1]. As a cell adhesion molecule, CD44, a widely expressed cell-surface glycoprotein and a cell-surface receptor for hyaluronate and osteopontin, is known to mediate cellular adhesion to the ECM, which is a prerequisite for tumor cell migration [2]. CD44 is the product of a single gene located on the short arm of human chromosome 11; the entire human CD44 gene is encoded by 60 kb of genomic DNA and contains 20 exons [3]. Its low molecular weight standard isoform, CD44s, binds more strongly to hyaluronate than high molecular weight CD44 isofo

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