Influencia de las hormonas sexuales en mujeres con esclerosis múltiple durante la memoria de trabajo y la activación cerebral medida con mapeo electroencefalográfico

Multiple Sclerosis is an inflammatory demyelinating CNS disease that occurs most often in women, suggesting that sex hormones appear to modulate the manifestation of symptoms. EEG activity has not been evaluated in women with MS during the processing of MT and hormonal status. The recordings were made in the follicular and luteal phases of the menstrual cycle a simultaneous cognitive task and EEG also were correlated with hormone levels. The luteal phase showed a better performance with a greater number of categories achieved (p <0.004), fewer perseverative errors (p <0.003) and greater number of trials to reach a category (p <0.011) was associated with increased theta activity (p <0.018) and Alpha 2 (p <0.000). 92% of the variability in the number of trials of the task was explained by the activity of Theta and Alpha 2, LH and estrone levels in the follicular phase, luteal phase, 90% of the variability was explained by the activity of theta, LH, progesterone and estradiol. The MT improvement in the luteal phase of the menstrual cycle, suggesting that progesterone seems to facilitate Theta activity.