Space-time clustering of childhood central nervous system tumours in Yorkshire, UK

Information was extracted on individuals aged 0-14 years, diagnosed with a CNS tumour between the 1st January 1974 and 31st December 2006 from the Yorkshire Specialist Register of Cancer in Children and Young People. Ordnance Survey eight-digit grid references were allocated to each case with respect to addresses at the time of birth and the time of diagnosis, locating each address to within 0.1 km. The following diagnostic groups were specified a priori for analysis: ependymoma; astrocytoma; primitive neuroectodermal tumours (PNETs); other gliomas; total CNS tumours. We applied the K-function method for testing global space-time clustering using fixed geographical distance thresholds. Tests were repeated using variable nearest neighbour (NN) thresholds.There was statistically significant global space-time clustering for PNETs only, based on time and place of diagnosis (P = 0.03 and 0.01 using the fixed geographical distance and the variable NN threshold versions of the K-function method respectively).There was some evidence for a transient environmental component to the aetiology of PNETs. However, a possible role for chance cannot be excluded.Central nervous system (CNS) tumours are the second most common childhood malignancy in resource-rich countries [1]. Aetiology is poorly understood, but is likely to involve both genetic and environmental factors. Putative environmental factors have been identified from case-control studies including maternal consumption of cured meats, fish, tea and coffee whilst pregnant, N-nitroso compounds, exposure to insecticides or pesticides, animals and farm life, electro-magnetic fields and lack of social contact during the first year of life [2-7]. A role for infectious agents has been postulated [8]. If infections that are non-ubiquitous and non-endemic are involved in disease aetiology, then among cases the distribution of births (for an early exposure) or diagnoses (for a later exposure) may exhibit seasonal variation and/or spa