RISC in Development; A Review on RNA Induced Silencing Complex and its Contribution to Cellular Differentiation

Messenger RNAs may be targeted by short 19-27 nt RNAs generally called Small none-coding RNAs (snRNAs), the role of miRNAs among other snRNAs has been more studied and is well known. Many researches show that all compartments of RISC, Proteins and miRNAs take part in this wide range of regulatory impacts. Ago protein homologs plus miRNAs and target mRNAs form a silencing complex in P-bodies which lead to either cleavage, conservation or surprisingly amplification of target mRNA or gene product. This article reviews conceptions which contribute directly or implicate this important post transcriptional mechanism’s function to differentiation or fate of pluripotent cells.