Multiple Gastrointestinal Stromal Tumors (GISTs) of Stomach in a Healthy 13 year-old Girl

Gastrointestinal stromal tumors (GISTs) are uncommon tumors of the gastrointestinal (GI) tract that occur predominantly in adults. These tumors originated from Cajal cells have positive mutations for KIT (CD117) or platelet-derived growth factor receptor (PDGFRA). GIST especially multiple GISTs are very rare in children and lacking mutations in KIT. We present a previously healthy 13 year- old girl with history of hematemesis and melena for two months which has caused severe anemia requiring ICU admission with final diagnosis of KIT positive multiple GISTs in stomach.