Nevadensin: Isolation, chemistry and bioactivity

Nevadensin (5,7-dihydroxy-6,8,4′-trimethoxyflavone) has already established itself as a promising natural bioactive substance that bears the potential to become a novel "natural lead" in drug discovery programmes. The bioflavonoid exhibited a wide range of significant biological activities including hypotensive, anti-tubercular, antimicrobial, anti-inflammatory, anti-tumour and anti-cancer activities. This review deals with natural sources, isolation, chemistry and biological activities of the flavonoid in detail. The present resume is aimed to boost the ongoing researches on pharmaceutically potential natural "lead molecules" in drug discovery programmes.