Hyperhomocysteinemia, a Risk Factor for Myocardial Infarction in Patients with Type-2 Diabetes in Southern Sindh, Pakistan

Hyperhomocysteinemia is a major risk factor for Myocardial Infarction (MI) in patients with type 2 diabetes, in general population of Pakistan. However, the role of increase plasma homocysteine level in the development of Coronary Heart Disease (CHD) in patients with type 2 diabetes is still unknown. Therefore this study was designed to determine the relation ship between plasma homocysteine level and the incidence of MI in patients with type 2 diabetes. The study group consists of 107 patients (71 male and 36 female) who are admitted in different hospital of Hyderabad and Mirpurkhas with myocardial infarction. Plasma total homocysteine level, lipid profile and HbA1c were measured. All patients were identified as diabetic by using WHO criteria. Group A indicates patients (Diabetes Mellitus [DM]) with Myocardial Infarction ([MI] n = 107) Group B include controls (non-Diabetes Mellitus [non-DM] having MI). The plasma homocysteine level was significantly high in patients then in control (21.3±1.8 Vs 13.9±1.2 μmol/L, p = 0.0008). It seems clear relationship between hyperhomocystenia and an increase risk of MI in patients with type 2 diabetes.