Thermodynamic Study of Trace Metal Complexes with Hydroxamate Drug of Iron overload.

The potentiometer data at different tempratures for hydroxamate drug and its trace metal complexes such as Al(III), Cr(III), Fe(III), Mn (II), Ca(II), Zn(II), Cd(II), Cu(II), Mg(II), Ni(II) and Co(II) were analysed by computer program "BEST". The values of these complexes at different tempratures were used to calculate the entropy and enthalpy values of complexes. The values of result showed that tripositive ions such as Fe(III), Al(III) and Cr(III) have high thermodynamic stability. Among dipositive ions Cu(II), have high values which are close to Fe(III), hence this drug has potential to disturb the equilibrium of Cu(II) as well.