A relation between hypothyroidism and membranous glomerulopathy

A 14 years old male patient referred to our clinic with generalized edema, weakness and faintness,which had initiated from 3 weeks ago. He had not any medical problems in his past history, only hisfather had history of hypothyroidism. In physical examination, he was pale and had ascite and lowerextremities edema. His vital signs were normal. Renal biopsy was carried out and showed membranousnephropathy. The patient was treated with levothyroxin. By increasing of drug doses, proteinuria wasgradually disappeared during 3 months and return to normal range completely. Therefore, werecommend that in all cases of nephrotic syndrome (massive proteinuria), thyroid function must beassessed and if the TSH level was higher than normal range, in the first step, levothyroxin isadministered for normalizing of thyroid function.