Comparison of AgNOR Count and AgNOR Surface Area/Total Nuclear Surface Area Proportions to Sex and Age in Cases with Cystic Nodular Goitre

Aim: Different proteins have different roles in various diseases. Argyrophilic nucleolar organising region associated proteins (AgNORs) are synthesized from secondary constriction of acrocentric chromosome interested in a variety of diseases including thyroid disorders.Our aim was the comparison of the AgNOR count and AgNOR surface area/total nuclear surface area (NORa/TNa) proportions to different sex and age in cases with cystic nodular goitre.Materials and Methods: Twenty female (age range 26-78) and male (age range 26-79) whose fine needle aspiration (FNA) materials were compatible with cystic nodular goitre were included in the study. Those biopsy materials were stained for AgNOR detection according to a specific protocol. 100 nuclei per individual have been evaluated, and both AgNOR count and NORa/TNa values of individual cells were detected for each group.Results: Female patients with cystic nodular goitre had not significantly (p=0.131) higher AgNOR count (2.05±0.46%) and NORa/TNa (6.53±1.21%) than in males (2.35±0.66% and 7.03±1.12%) (p=0.211), respectively. Additionally, there is not any correlation between age and AgNOR number (r=0.085 p=0.627) and NORa/T a ratio (r=0.286; p=0.096) in both of male and female.Conclusion: There is not any relationship between AgNOR protein synthesis and both of age and sex in cases with cystic nodular goitre.