A 13-year-old caucasian boy with cleidocranial dysplasia: a case report

A 13-year-old Caucasian boy presented with a chief complaint of delayed eruption of the permanent anterior teeth. The patient was subsequently diagnosed with CCD based on the clinical examination, panoramic X-ray, anterior-posterior and lateral cephalogram, and chest radiograph findings. The details of this case are herein reported because of the extremely low incidence of this disorder.CCD is of clinical importance in dentistry and medicine because it affects the bones and teeth and is characterized by many changes in skeletal patterning and growth. Particularly in dentistry, CCD is of great clinical significance because is associated with delayed ossification of the skull sutures, delayed exfoliation of the primary teeth, lack of permanent teeth eruption, multiple supernumerary teeth, and morphological abnormalities of the maxilla and mandible. Patients with CCD seek treatment mainly for dental problems. Knowledge of the pathogenesis, clinical characteristics, and diagnostic tools of CCD will enable clinicians to render the appropriate treatment to improve function and aesthetics. Early diagnosis of CCD is crucial for timely initiation of an appropriate treatment approach.Cleidocranial dysplasia (CCD) is a rare congenital skeletal disorder that affects the bones and teeth and shows an autosomal inheritance pattern. The disorder is characterized by hypoplasia or aplasia of the clavicles, delayed closure of the fontanelles, supernumerary teeth, short stature, and other changes in skeletal patterning and growth [1-3].Hereditary transmission of this syndrome was reported many years ago; however, the etiology and pathogenesis of the syndrome has remained unknown for many decades. Genetic studies of individuals from families bearing the syndrome, as well as experimental studies on transgenic mice, have presented new data regarding the syndrome’s clinical manifestation and type of hereditary transmission. The responsible gene for the pathogenesis of CCD has been mapped o