Chemical constituents of Breynia glauca leaves

From the leaves of Breynia glauca, eight compounds including friedelin (1), 3-oxo- 4,5-sitosterone (2), friedelan-3β-ol (3), β-sitosterol (4), kaempferol (5), arbutin (6), kaempferol-3-O-rutinoside (7) and quercetion-3-O-glucoside (8) were isolated. The presence of these compounds supports the traditional use of this plant as a detoxifying agent. In addition, all of these chemical constituents were tested for antiviral potential against herpes simplex virus types 1 and 2, but were found to be inactive at 50 μg/ml.