Bilateral Breast Asymmetry Detection using Intensity Histogram and Landmark based Registration Technique

Breast cancer is a serious health challenge faced all over the world. The cause of which is unclear so prevention is not possible. Effective monitoring by screening programs is the only solution for early detection and cure for this disease. Increasing awareness has led to mass screening programs that are generating huge number of mammograms that are required to be examined by radiologists. Determination of asymmetry between mammogram pairs may be indicative to the presence of possible abnormalities. Any change within the tissues results in variations in the anatomy of the organs. Such changes are also reflected, more often, morphologically in the shape and structure of the breasts. It is possible to detect the difference of structures and anatomy between the breast pair. In this paper we have developed algorithms and methodologies for CAD based determination of both morphological and anatomical asymmetry. The results obtained effectively identified both anatomical and morphological asymmetry in comparison to normal pairs.