Preparation and assessment cytotoxic and hemolytic activities of Complexes from “Chelating Kojic–Lipid Conjugate”

Complex bis (2-Oleicoyloxymethyl-5-hydroxy-gamma-pyrone) copper (II) and tris (2-Oleicoyloxymethyl-5-hydroxy-gamma-pyrone) iron (III) were prepared in ethanol using the structure "chelator conjugate kojic -lipid". This ester was obtained from kojic acid by improving their lipophilicity of obtaining metalobioactives with application in Medicinal Bioinorganic Chemistry. Through the technique ATR/FTIR, the values of the infrared kojic acid has been updated and it was possible to characterize the complex 1567m, 1511w (Cu (II)←[O=C]2), and 1540m, 1519m (Fe(III)←[O=C]3. These compounds no showed cytotoxic potential against B16 (melanoma) and ACP02 (gastric adenocarcinoma) (IC50> 5 μg mL-1) and low hemolytic activity (EC50> 250 μg mL-1).The preparation of these new molecules by structural modification techniques and these interesting biological results confirm the continuity of this studies related to these coordination complexes to glimpse the possibility of obtaining other derivatives/ analogues with significant biological potential of this metallo-bioactive.